Wednesday, September 7, 2016

Chlorpheniramine/Dextromethorphan/Phenylephrine Drops


Pronunciation: KLOR-fen-IR-a-meen/DEX-troe-meth-OR-fan/FEN-il-EF-rin
Generic Name: Chlorpheniramine/Dextromethorphan/Phenylephrine
Brand Name: Examples include AccuHist PDX Drops, Bronkids, and Sonahist DM Pediatric Drops


Chlorpheniramine/Dextromethorphan/Phenylephrine Drops are used for:

Relieving sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory tract infections, and allergies. It may also be used for other conditions as determined by your doctor.


Chlorpheniramine/Dextromethorphan/Phenylephrine Drops are a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.


Do NOT use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops if:


  • you are allergic to any ingredient in Chlorpheniramine/Dextromethorphan/Phenylephrine Drops

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you are taking droxidopa, sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Chlorpheniramine/Dextromethorphan/Phenylephrine Drops:


Some medical conditions may interact with Chlorpheniramine/Dextromethorphan/Phenylephrine Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of adrenal gland problems (eg, an adrenal gland tumor), heart problems (eg, fast, slow, or irregular heartbeat; heart disease), high or low blood pressure, low blood volume, diabetes, blood vessel problems, a stroke, glaucoma or increased pressure in the eye, or thyroid problems

  • if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea) or chronic obstructive pulmonary disease (COPD), or if your cough produces large amounts of mucus

  • if you have a history of stomach or bowel ulcers; a blockage of your stomach, bladder, or bowel; kidney problems; an enlarged prostate or other prostate problems; or trouble urinating

Some MEDICINES MAY INTERACT with Chlorpheniramine/Dextromethorphan/Phenylephrine Drops. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Digoxin or droxidopa because the risk of irregular heartbeat or a heart attack may be increased

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, linezolid, MAOIs (eg, phenelzine), selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram, fluoxetine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Chlorpheniramine/Dextromethorphan/Phenylephrine Drops's side effects

  • Barbiturates (eg, phenobarbital), bromocriptine, or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Chlorpheniramine/Dextromethorphan/Phenylephrine Drops

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Chlorpheniramine/Dextromethorphan/Phenylephrine Drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpheniramine/Dextromethorphan/Phenylephrine Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops:


Use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Chlorpheniramine/Dextromethorphan/Phenylephrine Drops by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

  • Use the dropper that comes with Chlorpheniramine/Dextromethorphan/Phenylephrine Drops to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If you miss a dose of Chlorpheniramine/Dextromethorphan/Phenylephrine Drops and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops.



Important safety information:


  • Chlorpheniramine/Dextromethorphan/Phenylephrine Drops may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlorpheniramine/Dextromethorphan/Phenylephrine Drops; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

  • Do not take diet or appetite control medicines while you are taking Chlorpheniramine/Dextromethorphan/Phenylephrine Drops without checking with your doctor.

  • Before you start any new medicine, check the label to see if it has a decongestant, antihistamine, or cough suppressant in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do not use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.

  • Do NOT exceed the recommended dose or take Chlorpheniramine/Dextromethorphan/Phenylephrine Drops for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 5 to 7 days, if they get worse, if they are accompanied by fever, or if your cough is accompanied by rash or persistent headache, check with your doctor.

  • Chlorpheniramine/Dextromethorphan/Phenylephrine Drops may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Chlorpheniramine/Dextromethorphan/Phenylephrine Drops. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Chlorpheniramine/Dextromethorphan/Phenylephrine Drops may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Chlorpheniramine/Dextromethorphan/Phenylephrine Drops for a few days before the tests.

  • Tell your doctor or dentist that you take Chlorpheniramine/Dextromethorphan/Phenylephrine Drops before you receive any medical or dental care, emergency care, or surgery.

  • Use Chlorpheniramine/Dextromethorphan/Phenylephrine Drops with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, nervousness, sleeplessness, and trouble urinating.

  • Caution is advised when using Chlorpheniramine/Dextromethorphan/Phenylephrine Drops in CHILDREN; they may be more sensitive to its effects, especially excitability.

  • Different brands of Chlorpheniramine/Dextromethorphan/Phenylephrine Drops may have different dosing instructions for CHILDREN. They may also be indicated for different age ranges of children. Follow the dosing instructions that your doctor has given you. If you are unsure of the dose to give to your child or if you are unsure if Chlorpheniramine/Dextromethorphan/Phenylephrine Drops are appropriate for your child, check with your doctor or pharmacist.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlorpheniramine/Dextromethorphan/Phenylephrine Drops while you are pregnant. It is not known if Chlorpheniramine/Dextromethorphan/Phenylephrine Drops are found in breast milk. Do not breast-feed while taking Chlorpheniramine/Dextromethorphan/Phenylephrine Drops.


Possible side effects of Chlorpheniramine/Dextromethorphan/Phenylephrine Drops:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth; excitability; headache; heartburn; loss of appetite; nausea; nervousness; trouble sleeping; upset stomach; vomiting; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; increased urination; loss of coordination; mental or mood changes (eg, depression); seizures; severe dizziness, drowsiness, lightheadedness, or headache; severe or persistent trouble sleeping; shortness of breath; tremor; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, double vision, severe or persistent blurred vision).



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Chlorpheniramine/Dextromethorphan/Phenylephrine side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately. Symptoms may include blurred vision; confusion; decreased coordination; excitability; fever; flushing; hallucinations; mental or mood changes; muscle spasms; restlessness; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor; trouble breathing; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Chlorpheniramine/Dextromethorphan/Phenylephrine Drops:

Store Chlorpheniramine/Dextromethorphan/Phenylephrine Drops between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpheniramine/Dextromethorphan/Phenylephrine Drops out of the reach of children and away from pets.


General information:


  • If you have any questions about Chlorpheniramine/Dextromethorphan/Phenylephrine Drops, please talk with your doctor, pharmacist, or other health care provider.

  • Chlorpheniramine/Dextromethorphan/Phenylephrine Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Chlorpheniramine/Dextromethorphan/Phenylephrine Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Chlorpheniramine/Dextromethorphan/Phenylephrine resources


  • Chlorpheniramine/Dextromethorphan/Phenylephrine Side Effects (in more detail)
  • Chlorpheniramine/Dextromethorphan/Phenylephrine Use in Pregnancy & Breastfeeding
  • Chlorpheniramine/Dextromethorphan/Phenylephrine Drug Interactions
  • Chlorpheniramine/Dextromethorphan/Phenylephrine Support Group
  • 6 Reviews for Chlorpheniramine/Dextromethorphan/Phenylephrine - Add your own review/rating


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